Head coach Warren Gatland named his side on Wednesday morning, and it includes both Lawes and Biggar.
It will be a debut Test appearance for the Lions for No.10 Biggar, and a maiden Lions Test start for Lawes, who packs down on the blindside flank having won his previous two Lions Test caps from the bench in New Zealand in 2017.
“In my four tours as a Lions coach, this was by far the hardest Test selection I have been involved in,” said Gatland.
“We couldn’t have asked for more from the players so far; they’ve all put their hands up and made picking a starting XV incredibly difficult. In truth, we would have been happy with any number of different combinations across the 23, however, we’re very pleased with the side we’ve settled on.
“We know what we’re coming up against on Saturday. It’s going to be an arm wrestle, there’s no doubt about it.
"We’ll need to front up physically and be ready to go from the first whistle.
"When we played South Africa ‘A’ last week we probably took a bit too long to get into the game, something we can’t afford to do that again this weekend.
“We need to make sure we play in the right areas of the field, not give them easy territory and take our chances when they come.
“While the stands will be empty in Cape Town Stadium, we know Lions fans from across the home nations will be cheering us on back home. We’ll do our best to get the win.”
SOUTH AFRICA v THE BRITISH & IRISH LIONS
Saturday, July 24, 2021
Cape Town Stadium, Cape Town
Kick-off: 5pm (BST)
15. Stuart Hogg (Exeter Chiefs, Scotland) #783
14. Anthony Watson (Bath Rugby, England) #816
13. Elliot Daly (Saracens, England) #822
12. Robbie Henshaw (Leinster Rugby, Ireland) #824
11. Duhan van der Merwe (Worcester Warriors, Scotland) #841
10. Dan Biggar (Saints, Wales) #821
9. Ali Price (Glasgow Warriors, Scotland) #843
1. Wyn Jones (Scarlets, Wales) #842
2. Luke Cowan-Dickie (Exeter Chiefs, England) #851
3. Tadhg Furlong (Leinster Rugby, Ireland) #818
4. Maro Itoje (Saracens, England) #825
5. Alun Wyn Jones – captain (Ospreys, Wales) #761
6. Courtney Lawes (Saints, England) #826
7. Tom Curry (Sale Sharks, England) #853
8. Jack Conan (Leinster Rugby, Ireland) #839
16. Ken Owens (Scarlets, Wales) #829
17. Rory Sutherland (Worcester Warriors, Scotland) #840
18. Kyle Sinckler (Bristol Bears, England) #814
19. Tadhg Beirne (Munster Rugby, Ireland) #838
20. Hamish Watson (Edinburgh Rugby, Scotland) #847
21. Conor Murray (Munster Rugby, Ireland) #790
22. Owen Farrell (Saracens, England) #780
23. Liam Williams (Scarlets, Wales) #833