Saints duo handed starts for Six Nations finale

Furbank will win his third cap as he lines up at full-back for England in their game against Italy at the Stadio Olimpico (kick-off 4.45pm GMT).

Biggar is at fly-half for Wales and will earn his 85th cap in the clash with Scotland in Llanelli (kick-off 2.15pm GMT).

Wales can't win the Six Nations as they currently sit seven points behind Ireland, who lead the way.

But Furbank and England could be celebrating as they are just one point adrift in second and Ireland face a tough final encounter, away to France, on Saturday evening (kick-off 8.05pm GMT).

England boss Eddie Jones said: “We’ve trained with good intensity this week and the squad are excited by the challenge of performing at our best against Italy.

“The team have prepared well and are looking forward to putting on an England shirt and showing what they can do."

England team to face Italy

15. George Furbank (Saints, 2 caps)

14. Anthony Watson (Bath Rugby, 43 caps)

13. Jonathan Joseph (Bath Rugby, 50 caps)

12. Henry Slade (Exeter Chiefs, 29 caps)

11. Jonny May (Gloucester Rugby, 56 caps)

10. Owen Farrell (Saracens, 83 caps)

9. Ben Youngs (Leicester Tigers, 99 caps)

1. Mako Vunipola (Saracens, 59 caps)

2. Jamie George (Saracens, 49 caps)

3. Kyle Sinckler (Bristol Bears, 35 caps)

4. Maro Itoje (Saracens, 38 caps)

5. Jonny Hill (Exeter Chiefs, uncapped)

6. Tom Curry (Sale Sharks, 23 caps)

7. Sam Underhill (Bath Rugby, 18 caps)

8. Billy Vunipola (Saracens, 51 caps)

Replacements

16. Tom Dunn, (Bath Rugby, uncapped)

17. Ellis Genge (Leicester Tigers, 18 caps)

18. Will Stuart (Bath Rugby, 3 caps)

19. Charlie Ewels (Bath Rugby, 15 caps)

20. Ben Earl (Bristol Bears, 3 caps)

21. Dan Robson (Wasps, 2 caps)

22. Ollie Lawrence (Worcester Warriors, uncapped)

23. Ollie Thorley (Gloucester Rugby, uncapped)