Leicester Tigers v Northampton Saints: Team news for Saturday's game at Welford Road
Isiekwe suffered a pectoral injury during the win against London Irish last Friday and he has been replaced in the starting line-up by Tom Wood.
One injury boost for Saints comes in the form of Matt Proctor who is fit enough to return from a calf problem, taking the place of Tom Collins on the wing.
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Hide AdRory Hutchinson replaces Fraser Dingwall at outside centre in the only other change to the backline.
In the pack, Alex Waller, Sam Matavesi and Ehren Painter replace Nick Auterac, Mike Haywood and Paul Hill.
Tommy Freeman has recovered from the knee injury he picked up against Ulster and is able to be named among the replacements.
Saints remain without Taqele Naiyaravoro (calf), Owen Franks (foot), Danny Hobbs-Awoyemi (Achilles), Courtney Lawes (pectoral), Api Ratuniyarawa (shoulder), Ryan Olowofela (ankle) and Kayde Sylvester (Achilles).
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Hide AdLeicester Tigers: Steward; van Wyk, Scott, Kelly, Murimurivalu; Ford, B Youngs; Genge, T Youngs (c), Cole; Wells, Green; Liebenberg, Wallace, Wiese.
Replacements: Clare, de Bruin, Heyes, Lavanini, Brink, van Poortvliet, Henry, Nadolo.
Saints: Furbank; Proctor, Hutchinson, Francis, Sleightholme; Biggar, Mitchell; Waller (cc), Matavesi, Painter; Ribbans, Moon; Wood, Ludlam (cc), Harrison.
Replacements: Haywood, Auterac, Hill, Coles, Adendorff, James, Tuala, Freeman.