But Teimana Harrison, who has recently recovered from a hand injury, has suffered a new problem, with a groin issue keeping him out of the Gallagher Premiership game.
Earlier in the week, Saints boss Chris Boyd reported that Harrison had returned to training, while there were doubts around Proctor and Francis, who were described as 'a bit ginger'.
But both backs have made it and will start at the Twickenham Stoop.
Francis has a new centre partner, with Fraser Dingwall given the nod ahead of Rory Hutchinson, who is among the replacements.
Ollie Sleightholme returns to the starting 15 in place of Taqele Naiyaravoro, who is not in the matchday squad.
In the pack, Paul Hill comes in for Ehren Painter at tighthead, while Alex Coles steps in for David Ribbans, who is now with England.
JJ Tonks could get a taste of the action, with the flanker named on the bench.
Dan Biggar is not involved but is expected to be fit enough to feature for Wales in their Six Nations match next weekend.
On the Saints injury list at present are Harrison, Shaun Adendorff (knee), Owen Franks (foot), Danny Hobbs-Awoyemi (Achilles), Courtney Lawes (pectoral) and Kayde Sylvester (Achilles).
Harlequins: Brown; Morris, Marchant, Esterhuizen, Green; Smith, Care; Marler, Baldwin, Louw; Lamb, Lewies (c); J Chisholm, White, Dombrandt.
Replacements: Gray, Els, Kerrod, Young, Kenningham, Landajo, Herron, Northmore.
Saints: Freeman; Proctor, Dingwall, Francis, Sleightholme; Furbank, James; Auterac, Matavesi, Hill; Coles, Ratuniyarawa; Isiekwe, Ludlam (c), Wood.
Replacements: Haywood, Waller, Painter, Moon, Tonks, Taylor, Hutchinson, Mallinder.