Ben Drinkwater struck twice as Weedon eased to a 5-2 win over UCL outfit Thrapston Town Reserves in the NFA Lower Junior Cup.
Thomas Murfitt, Joe Shirley and Ashley Brown were also on target as Weedon booked their place in round three.
Matthew Russ and Chris Trill both hit hat-tricks as Daventry Drayton Grange hammered Kettering Nomads Reserves to progress.
Daniel Wilkes scored twice in the win, while there were singles from Jamie Sedgley, Darren Taylor and Adam Cox.
Heyford Athletic secured a 2-0 win at UCL opposition in Rothwell Corinthians Reserves.
In the Duston Garage Reserve Division One Cup, Weedon Reserves are out after losing 3-1 to holders Weldon United A.
Weedon netted through Matthew Farrell, but Weldon won it with goals from Arran John Brown, Martin Collins and David O’Neill.
In the Duston Garage Reserve Division Two Cup, Bugbrooke B went through thanks to a 4-2 win over West Haddon Reserves.
In Duston Garage Reserve Division Two, Daventry Drayton Grange Reserves remain second after a 6-3 win over Kettering Orchard Park Reserves.
Alex O’Connor (2), Ryan Barrett, Rhys Collins, Joe Pidgeon and David Robinson were all on target.
Gentran Shahollaric scored twice as Heyford Reserves comfortably saw off lowly Corby United Reserves 6-2.
Mark Royle, Ben Richards, Taylor Morgan and George Underwood also netted.