Katie Kelly and her daughter were last seen yesterday in the Daventry area.
Officers are concerned for their safety and believe they may be in the Northampton area.
Katie is described at 5ft 7ins, slim build, long, dark brown, straight hair and green eyes.
She was wearing a diamond effect bracelet and gold locket. She had black leggings on, a white t-shirt and trainers
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Anyone with any information can call Northamptonshire Police on 101. Alternatively, they can call the independent charity Crimestoppers anonymously on 0800 555 111 or use the anonymous online form at www.crimestoppers-uk.org.