Stephen Myler and Alex Waller have missed out on a place in the England squad for the third Test against New Zealand in Hamilton on Saturday.
Myler will depart the tour having not played a single minute of Test match action, with Freddie Burns the preferred choice at 10 in the absence of the injured Owen Farrell.
Danny Cipriani, who started in the 38-7 win against Super Rugby side Crusaders on Tuesday, gets the place on the bench.
Waller, like Myler, who was a second-half replacement, played his part in the midweek success, starring from the start on his debut for Stuart Lancaster’s team.
But the Saints prop has not done enough to force his way into Lancaster’s plans as England look to claim a consolation victory, having lost the first two Tests.
Dylan Hartley and Courtney Lawes return to the starting line-up, having begun the second Test on the bench, while Tom Wood keeps his place in the back row.
Lee Dickson and Luther Burrell, who sees Manu Tuilagi take his No.13 shirt, are among the replacements.
“We want to finish the tour and the season on a high and we have a fantastic opportunity on Saturday,” said England head coach Lancaster.
“Our aim was to win a Test series and we are disappointed that we haven’t but I am confident the players selected will go all out to achieve the win on Saturday.
“We have progressed as a squad during this tour and while there has been challenges with the end of season scheduling affecting selection, it has been a great opportunity to work with a wider group of players and test many of them at the highest level in the build up to the World Cup.”
England: Brown; Ashton, Tuilagi, Eastmond, Yarde; Burns, Care; Marler, Hartley, Wilson; Lawes, Parling; Wood, Robshaw, B Vunipola.
Replacements: Webber, Mullan, Brookes, Launchbury, Morgan, Dickson, Cipriani, Burrell.